Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation

Aim: The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients physico-chemical parameters new drug substance. This could provide important information for design or support need molecular modification. So, in present studies were performed on Glimepiride (GMP) assess its suitability parenteral formulation. first IIIrd generation sulphonyl urea used treat type –II diabetes mellitus.
 Methods: authenticity GMP was established DSC FTIR spectra. A UV spectrophotometric method HPLC employed determination bulk active pharmaceutical ingredient (API).
 Results: linear range 3-10 μg/ml. low % CV values intra-day inter-day variations revealed that proposed robust. retention time found be 1.9 min. proven robust obtaining very high regression coefficient value (0.999).
 Conclusions: results physicochemical route. Moreover, stable both solid as well liquid state at different conditions.